Paradoxical sleep deprivation induces muscle atrophy

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Paradoxical sleep deprivation induces muscle atrophy

Postby galapogos » Mon Apr 02, 2012 10:45 am

Paradoxical sleep deprivation induces muscle atrophy

INTRODUCTION:
Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats.

METHODS:
Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle.

RESULTS:
PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels.

CONCLUSION:
PSD induces hormonal alterations that may mediate muscle atrophy.

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Re: Paradoxical sleep deprivation induces muscle atrophy

Postby Canuck eh » Mon Apr 02, 2012 3:34 pm

Not really news, but that sucks..
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